Dr John Campbell < Control Group

Dr John Campbell is a Nursing Educator in the UK medical system, and great analyst of covid,, health care, anatomy, and statistics. While a proponent of vaccination, he uncovered evidence for Vitamin D, Zinc, and Ivermectin from around the world early on in the pandemic, and is still shocked that there is no money for study. As we have pointed out to him, as a lifetimer in UK socialized medicine, he is 5000 miles away from the graft.

Comorbid diseases

US, Risk factors for severe CoViD

https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/people-with-medical-conditions.html

https://www.statista.com/statistics/1191568/reported-deaths-from-covid-by-age-us/

Cancer

The disease and some treatments

Chronic kidney disease

Chronic lung diseases

chronic obstructive pulmonary disease

asthma

interstitial lung disease

cystic fibrosis

pulmonary hypertension

Dementia or other neurological conditions

Diabetes

Type 1

Type 2

Down syndrome

Heart conditions

heart failure

coronary ...artery disease

cardiomyopathies

hypertension

HIV infection

Immunocompromised

primary immunodeficiency

prolonged use of corticosteroids

other immune weakening medicines

Liver disease

chronic liver disease

alcohol-related liver disease

non-alcoholic fatty liver disease

especially cirrhosis
Overweight and obesity

overweight

obesity

severe obesity

Pregnancy

And for at least 42 days following end of pregnancy

Sickle cell disease or thalassemia

Smoking, current or former

Solid organ or blood stem cell transplant

Stroke or cerebrovascular disease

Substance use disorders

alcohol, opioid, or cocaine

Children with underlying medical conditions are at increased risk

Actions You Can Take

Continue your medicines

Follow your current treatment plan

Have at least a 30-day supply of meds

Have shelf-stable food choices available

Know the triggers

Learn about stress and coping

Do not delay getting emergency care for your medical condition

Call your healthcare provider if you have any concerns

When possible, keep preventive care and other routine healthcare appointmentsShow More

Comorbid diseases

US, Risk factors for severe CoViD ...

Global disinformation

Mystery anti-Pfizer campaign offer ...

Mystery anti-Pfizer campaign offer

https://www.bbc.co.uk/news/world-europe-57250285

Several French social media influencers

Mysterious financial offer to spread negative publicity about Pfizer vaccine

Leo Grasset on YT

https://www.youtube.com/watch?v=dSlh4ONU01M

Colossal budget was offered

from a client who wants to remain incognito

address ...the agency appeared to be bogus

LinkedIn profiles of the agency's alleged employees he had managed to find later disappeared

he noticed that everybody there has worked in Russia

Present the material as your own independent view

false claim, Pfizer deaths 3 times that of AstraZeneca

Et Ça Se Dit Médecin, offered €2,050 ($2,510; £1,775) for a 30-second story on his account

European External Action Service

The European External Action Service is the diplomatic service and combined foreign and defence ministry of the European Union.

https://euvsdisinfo.eu/eeas-special-report-update-short-assessment-of-narratives-and-disinformation-around-the-covid-19-pandemic-update-december-2020-april-2021/

Disinformation around the COVID-19 pandemic, measures taken to contain it and vaccine roll-out campaigns continues to be significant.

vaccine-related disinformation increased and contributed to spreading fear and mistrust in any type of vaccine.

since the beginning of 2021 state-sponsored disinformation also intensified, targeting in particular Western-developed vaccines.

Russia and China, in particular, continue to intensively promote their own state-produced vaccines around the world.

is combined with disinformation and manipulation efforts to undermine trust in Western-made vaccines, EU institutions and Western/European vaccination strategies.

Both Russia and China are using state-controlled media, networks of proxy media outlets and social media, including official diplomatic social media accounts, to achieve these goals.

Viral origins

https://www.foxnews.com/politics/fauci-not-convinced-covid-19-developed-naturally

Q, Katie Sanders

are you still confident that it developed naturally?

A, Dr Fauci

No actually

I am not convinced about that

I think we should continue to investigate what went on in China until we continue to find out to the best of our ability what happened

Certainly, the people who investigated it say it likely was the emergence from an animal reservoir that then infected individuals

but it could have been something else, and we need to find that out

WHO-convened global study of origins of SARS-CoV-2: China Part

https://www.who.int/publications/i/item/who-convened-global-study-of-origins-of-sars-cov-2-china-part

Team of 17 international experts

Unknown animal species, very likely

Lab-leak idea extremely unlikely

Imported on frozen food

President Biden

https://www.washingtonpost.com/world/2021/05/27/wuhan-lab-theory-evidence/

U.S. intelligence community does not believe there is sufficient information on different scenarios

asking the U.S. intelligence community to redouble its efforts

partner with like-minded partners around the world to press China to participate in a full, transparent, evidence-based international investigation

World Health Assembly, calls to significantly expand upon the WHO-backed investigation

Open letter

https://science.sciencemag.org/content/372/6543/694.1

greater clarity about the origins of this pandemic is necessary and feasible to achieve

We must take hypotheses about both natural and laboratory spillovers seriously until we have sufficient data.

A proper investigation should be transparent, objective, data-driven, inclusive of broad expertise, subject to independent oversight

theories of accidental release remained viableShow More

New evidence

Error, So sorry, of course the liver is on the right and the spleen on ...

Error, So sorry, of course the liver is on the right and the spleen on the left, dont know how I managed to get that worng.
Thrombocytopenia and splenic platelet directed ...immune responses after intravenous ChAdOx1 nCov-19 administration

https://www.biorxiv.org/content/10.1101/2021.06.29.450356v1.abstract?%3Fcollection=

Recently a rare and novel complication of SARS-CoV-2 targeted adenovirus vaccines has emerged:

thrombosis with thrombocytopenia syndrome (TTS)

Low platelets, clot formation at unusual sites and platelet-activating PF4-polyanion antibodies (reminiscent of heparin-induced thrombocytopenia).

In vitro and in vivo models

Platelet-targeted autoimmunity

We show that intravenous but not intramuscular injection of ChAdOx1 nCov-19 triggers platelet-adenovirus aggregate formation and platelet activation.

After intravenous injection, these aggregates are phagocytosed by macrophages in the spleen

This is followed by a pronounced B-cell response with the emergence of circulating antibodies binding to platelets.

Our work contributes to the understanding of TTS and highlights accidental intravenous injection as potential mechanism for post-vaccination TTS.

Hence, safe intramuscular injection, with aspiration prior to injection, could be a potential preventive measure when administering adenovirus-based vaccines.

Consistent results with mice and human platelets

Vaccines are routinely administered intramuscularly (i.m.) and trigger immune responses mainly in the draining lymph nodes

Based on our finding that adenoviral vaccine binds to blood platelets, we hypothesized that accidental intravenous injection of adenoviral vaccine might lead to platelet-adenovirus aggregate formation with platelet activation

The decline in platelet count was dose-dependent and correlated directly with adenovirus-positive platelets circulating in the blood one hour after i.v. injection

Intravenous but not i.m. injection of ChAdOx1 nCov-19 resulted in a strong increase in platelet-adenovirus aggregates

Authors

Medizinische Klinik und Poliklinik I University Hospital Ludwig-Maximilian University Munich, Germany

DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Germany

Medizinische Klinik und Poliklinik III University Hospital Ludwig-Maximilian University Munich, Germany

Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific, Institute, Milan, Italy.

Previous peer reviewed evidence

Intravenous administration of recombinant adenoviruses causes thrombocytopenia, anemia and erythroblastosis in rabbits, (Journal of Gene Medicine, 1999)

https://pubmed.ncbi.nlm.nih.gov/10738553/

The systemic administration of a therapeutic dose of 5 x 10(11) infectious particles/kg (infusion time 20 min) led to an average reduction of 80-90% in the platelet count within 48 h.

Adenovirus-induced thrombocytopenia: the role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance, (Blood, 2007)

https://pubmed.ncbi.nlm.nih.gov/17148587/

Thrombocytopenia has been consistently reported following the administration of adenoviral gene transfer vectors.

The virus activates platelets and induces platelet-leukocyte aggregate formation.

Polyethylene glycol modification of adenovirus reduces platelet activation, endothelial cell activation, and thrombocytopenia, (Human gene therapy, 2007)

https://pubmed.ncbi.nlm.nih.gov/17767399/

Thrombocytopenia is one of the complications for in vivo administration of adenovirus serotype 5 (Ad5) vectors after intravenous injection.

Platelet-adenovirus vs. inert particles interaction: effect on aggregation and the role of platelet membrane receptors, (Platelets, 2013)
https://pubmed.ncbi.nlm.nih.gov/22812520/

Virus mediated gene therapy applications are still challenged by the resultant thrombocytopenia and the mechanism(s) of platelet-foreign particles interaction remains unclear.

Pseudotyping Serotype 5 Adenovirus with the Fiber from Other Serotypes Uncovers a Key Role of the Fiber Protein in Adenovirus 5-Induced Thrombocytopenia, (Human gene therapy, 2016)

https://pubmed.ncbi.nlm.nih.gov/26757054/Show More

Virus confirmed, March 2019

Viral origins ...

Post vaccine myocarditis update

Myocarditis update Israel 5 million vaccinations, 62 cases ...

Increasing antibody prevalence

ONS antibody survey, May 18th ...

Ivermectin prophylactic study from India

Ivermectin in India, Prophylactic role of ivermectin in SARS-CoV-2 ...

Ivermectin in India, Prophylactic role of ivermectin in SARS-CoV-2 infection among healthcare workers

https://www.aiims.edu/en.html

https://assets.researchsquare.com/files/rs-208785/v1/d6ff79a3-d354-4aba-a6b0-4bc123bbd225.pdf

https://www.researchsquare.com/article/rs-208785/v1

Background

Healthcare workers (HCWs) are vulnerable to getting infected withSARS-CoV-2

Preventing HCWs from getting infected is a priority to ...maintain healthcare services

The therapeutic and preventive role of ivermectin in COVID-19 is being investigated

Based on promising results of in vitro studies of oral ivermectin,

this study to look at prophylactic role of oral ivermectin

Methods

Prospective cohort study was conducted at AIIMS Bhubaneswar

Two-doses of oral ivermectin, 300 μg/kg at a gap of 72 hours

Primary outcome, COVID-19 infection in the month following

Of 3892 employees,

3532 (90.8%) participated in the study

Ivermectin uptake n = 2, 384 (67.5%)

Non uptake, n = 1147 (32.5%)

Results

Development of symptomatic infection

331 participants, developed symptoms

131 in takers

200 from non takers

Ivermectin takers, 6%

Non takers, 15%

Testing positive, 201

Ivermectin takers, 2%

Non takers, 11.7%

Implications for transmission

HCWs who had taken two-doses

(Single dose did not reach significance)

Significantly lower risk of contracting COVID-19 disease during the following month was 0.18

Adjusted Relative Risk 0.17

1.8% reported adverse events, mild and self-limiting

Conclusion and relevance

Two-doses of oral ivermectin (300 μg/kg given 72 hours apart) as chemoprophylaxis among HCWs

reduces the risk of COVID-19 infection by 83% in the following month.

Safe, effective, and low-cost chemoprophylaxis have relevance in the containment of pandemic
alongside vaccine.

https://www.pharmaceutical-technology.com/news/aiims-study-covid-19/

AIIMS Director, Gitanjali Batmanabane

Earlier, at least 20 to 25 HCWs were getting infected with the virus daily.

After the workers started taking ivermectin, the number of infection has come down to one or two per day

Critique

The safety of the drug has been established by its large-scale use in the last four decades for
various indications such as onchocerciasis, scabies, head lice, and other parasitic infestations

https://www.facebook.com/john.l.campbell1/

https://healthfeedback.org/claimreview/ivermectin-isnt-a-highly-effective-drug-for-treating-covid-19-tess-lawrie/?fbclid=IwAR2ahWjmOXuMx2u6FKgF9wTCESwHtN9EXKiKsTWCOoAygBb_P5thfAyOilAShow More

Virus in Italy, September 2019

Unexpected detection of SARS-CoV-2 antibodies in the prepandemic ...

Unexpected detection of SARS-CoV-2 antibodies in the prepandemic period in Italy

https://pubmed.ncbi.nlm.nih.gov/33176598/

https://journals.sagepub.com/doi/10.1177/0300891620974755?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed&

Presence of SARS-CoV-2 receptor-binding domain (RBD)-specific antibodies

Blood samples of 959 asymptomatic individuals enrolled in a prospective lung cancer screening trial

Italy's ...first two cases of COVID-19 disease

January 30, 2020, two tourists from China in Rome

First laboratory-confirmed Italian COVID-19 case, Lombardy on February 20, 2020,

September 2019 to March 2020

SARS-CoV-2 RBD-specific antibodies were detected in 111 of 959 (11.6%) individuals

IgM and some IgG

September 2019, 23/111

October, 27/111

November, 26/111

December, 11/111

January, 3/111

February, 21/111

Unexpected very early circulation of SARS-CoV-2 among asymptomatic individuals in Italy

At least one SARS-CoV-2–positive patient was detected in 13 regions

IgM antibodies were detected in 97 (10.1%) patients

IgG antibodies were found in 16 (1.7%)

All the patients were asymptomatic at the time of
blood sample collection.

First IgM detected 3rd September

Infection more widespread than believed

Therefore an overestimation of the mortality rate

Since November to December 2019

Many general practitioners began reporting severe respiratory symptoms in elderly
and frail people

Atypical bilateral bronchitis

(? organising pneumonia)

Attributed to aggressive forms of seasonal influenza.

National Library of Medicine

https://pubmed.ncbi.nlm.nih.gov/32371096/

Paris, December 2019

Patient hospitalized for hemoptysis

Stored nasopharyngeal swab confirmed the diagnosis of

SARS-CoV-2 infection.

Harvard Library, Since autumn 2019

https://dash.harvard.edu/handle/1/42669767

Increase of hospital traffic in the Wuhan region

Satellite imagery

COVID-19 symptoms–related queries in search engines

Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19

https://www.nejm.org/doi/full/10.1056/NEJMc2103916?emp=marcom&utm_source=nejmlist&utm_medium=email&utm_campaign=aomev2&utm_content=version-c

Moderna mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Efficacy 94% in phase 3 trials

Durability of protection, 180 days after 2nd dose

Antibody activity remained high in all age groups at day 209

Results are consistent with convalescent patients with Covid-19 through 8 months after symptom onset

Support the use of this vaccine in addressing the Covid-19 pandemic.Show More

Heart inflammation in Israel

Global India Cases, + 352,991 + 323,144 = 17,640,000 Deaths, + 2,800 = ...

Global
India
Cases, + 352,991 + 323,144 = 17,640,000

Deaths, + 2,800 = 197,894

Thriving black market

Underprepared governments

US allowing exports of vaccine components

US, 60 million AZ doses for export

US sends medical supplies

No intellectual property ...wavers

UK sends medical aid

Spain sends medical aid

Germany sending in a few days

ONS, week ending 16th April

https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/articles/coronaviruscovid19roundup/2020-03-26

England

Prevalence, 90,000 people (0.17%) in the community

(W/E 10th April, 112,600)

One in 610 people

Wales

Prevalence, 3,600 people (0.12%)

(W/E 10th April, 3,300)

One in 840 people

Northern Ireland

Prevalence, 2,800 people (0.15%)

(W/E 10th April, 2,600)

One in in 660 people

Scotland

Prevalence, 9,300 people (0.18%)

(W/E 10th April, 10,500)

One in 560 people

England and Wales, CoViD deaths 3.5% of all deaths in the week

Now

https://coronavirus.data.gov.uk

United States

https://covid.cdc.gov/covid-data-tracker/#trends_dailytrendscases

J&J/Janssen Update

https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/JJUpdate.html

CDC and the U.S. Food and Drug Administration (FDA) recommend use

Reports suggest an increased risk of a rare adverse event called thrombosis with thrombocytopenia syndrome (TTS)

Nearly all reports, adult women younger than 50 years old

Potential benefits outweigh known and potential risks

Women younger than 50 years old should be aware

there are other COVID-19 vaccine options available

For three weeks after receiving the vaccine

lookout for possible symptoms of a blood clot with low platelets

Severe or persistent headaches or blurred vision

Shortness of breath

Chest pain

Leg swelling

Persistent abdominal pain

Easy bruising or tiny blood spots under the skin beyond the injection site

Pfizer, Israel

https://www.timesofisrael.com/israel-said-probing-link-between-pfizer-shot-and-heart-problem-in-men-under-30/

https://www.reuters.com/article/us-health-coronavirus-israel-pfizer-idCAKBN2CC0J1

Channel 12 reported Friday

More than 5 million people vaccinated

62 recorded cases of myocarditis

56 of those cases came after the second shot

Most of the affected were men under 30.

60 of the patients were treated and released from hospital in good condition

2 deaths (22-year-old woman and a 35-year-old man)

details had also been sent to the US FDA and CDC, who were also investigating

one possible reason for lack of similar findings in other countries was the low rate of vaccinations among young people

There is specific concern regarding the frequency of the occurrence observed in men under 30 in the days immediately after the second shot

At this stage, according to initial findings that still need to be verified, there is an impression that the number (of cases) is higher than would be expected, especially for those under 30

Overall findings, 1-in-100,000

Aged 16 – 30 years, 1-in-20,000

We cannot yet tell if there are more cases than normal or if there are similar numbers annually and the proximity is just a coincidence.

Efforts to collect more data are continuing

Israel, children aged 12-15, when US Food and Drugs Administration approves

Health Ministry Director-General Chezy Levi

Once that age group has been vaccinated, the country will reach herd immunity

Therefore no need to vaccinate younger children

Vaccine choice, may be:

Younger women, Pfizer

Younger men, JanssenShow More

Vitamin D deficiency in India

Vitamin D deficiency in India ...

Vitamin D deficiency in India
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060930/

Prevalence of Vitamin D deficiency ranged from 40% to 99%

Most of the studies reporting a prevalence of 80%–90%

Prevalent in all the age groups and high-risk groups ...alike

Factors

Major source, synthesis in skin on exposure to sunlight

Ultraviolet B (UV-B) radiation, wavelength 290–320 nm

Fish, fortified food, supplements

Vegetables and grains are poor sources

Latitude, solar zenith angle, atmospheric pollution, ozone layer, and melanin pigmentation

Defining levels

Threshold levels of serum 25(OH) D required to optimize effects may vary in the various target organs

Deficiency, less than 20 ng/ml (50 nmol/L)

Insufficiency, 21 – 29 ng/ml (52 - 72 nmol/L)

Sufficiency, more than 30 ng/ml (75 nmol/L)

Toxicity, more than 150 ng/ml (375 nmol/L)

Desirable and safe range of serum 25(OH) D level would be 30–100 ng/mL (75 – 250 nmol/L)

Metabolism

Vitamin D is needed to facilitate calcium absorption from the gut

PTH is secreted in response to low blood serum calcium

Maintains serum calcium by moving calcium from bones to blood

At less than 20 ng/mL of serum 25(OH) D, PTH is elevated to maintain serum calcium from bony reserves

At serum 25(OH) D levels of intestinal calcium absorption reaches its peak,

and PTH levels continue to fall up to levels 30 ng/mL

Consequences of Vitamin D deficiency

Rickets

Muscle strength reduction

Autoimmune diseases

Cardiovascular diseases

Depression

Suicide

Parkinson’s

Cancer

Infections

Tuberculosis

Obesity

Diabetes mellitus type 2

Important for:

Immune function

Inflammation

Cell proliferation and differentiation

What to do

Create awareness among the public and healthcare providers about the importance of Vitamin D

and the consequences of deficiency

Indian diet generally fails to satisfy the daily requirement of Vitamin D for a normal adult

Need for fortifying various foods with Vitamin D, through national programs

This silent epidemic should be addressed appropriately with concrete public health action.

we can imagine the burden, this silent epidemic would cause the development of the country.Show More

The Vitamin D debate with Professor Spector

Many thanks to Tim and the Zoe team who made this possible.

Vitamin D studies confirm correlations

Vitamin D UK biobank https://www.ukbiobank.ac.uk Habitual use of ...

Vitamin D

UK biobank

https://www.ukbiobank.ac.uk

Habitual use of vitamin D supplements and risk of coronavirus disease 2019 (COVID-19) infection: a prospective study in UK Biobank (29th January, 2021)

https://academic.oup.com/ajcn/advance-article/doi/10.1093/ajcn/nqaa381/6123965

The American Journal of Clinical Nutrition

Background ...

Vitamin D supplementation, lower risk of acute respiratory tract infection

Emerging evidence, vitamin D insufficiency is related to a higher risk of coronavirus infection and disease

Objectives

To investigate the prospective association between habitual use of vitamin D supplements and risk of COVID- 19 infection

Associations according to levels of circulating and genetically predicted vitamin D

Methods

N = 8,297 adults

Records of COVID-19 test results from UK Biobank

16 March 2020 to 29 June 2020

Results

Of the 8,297 adults, 1,374 (16.6%) tested positive

Vit D users, n = 363

Non-vit D users, n = 7,934

Unadjusted model

OR 0.78 (p = 0.105)

Adjustment for covariates

Age, sex, race, origin (outpatient or inpatient), blood-type, years of education, TDI, smoking, moderate drinking, physical activity, healthy diet score, use of any other supplements

Inverse association emerged

Between habitual use of vitamin D supplements and risk of COVID-19 infection

OR, 0.66, (P = 0.038)

Habitual use of vitamin D supplements was significantly associated with a 34% lower risk of COVID-19 infection

No association with baseline blood vitamin D levels and risk of COVID-19 infection

Associations between the risk of COVID-19 infection and habitual use of other individual supplements

Vitamin A, vitamin B, vitamin C, vitamin E, folic acid, a
multivitamin,

Calcium, zinc, iron, selenium, glucosamine, fish
Oil

Vitamin D Deficiency and Outcome of COVID-19 Patients

Medical University Hospital Heidelberg, (September 2020)

https://www.mdpi.com/2072-6643/12/9/2757

Identification of modifiable prognostic factors may help to improve outcomes

N = 185, diagnosed and treated in Heidelberg

Median Vitamin D level was 16.6 ng/ml

Associations of vitamin D status with disease severity and survival

Vitamin D status assessed at first presentation

Deficient

25-hydroxyvitamin D (Calcifediol)
level less than 12 ng/mL ( less than 30 nM)

N = 41 (22%)

Median IL-6 levels at hospitalization were significantly higher

70.5 versus 29.7 pg/mL

Insufficiency

Less than 20 ng/mL (less than 50 nM)

N = 118 (64%)

Higher levels

N = 26

Median Vitamin D level was significantly lower in the inpatient versus the outpatient subgroup

Results

Median observation period of 66 days

93 (50%) patients required hospitalization

28 patients required ventilation

Including 16 deaths

Adjusting for age, sex, comorbidities

Deficiency was associated with higher risk of ventilation and death

Mechanical ventilation

HR 6.12

p less than 0.001

Death

HR 14.73

p less than 0.001

Other hazard ratios

Male, 1.69 2.5

Over 60, 3.2 7.7

Comorbidity, 2.7 5.3

Need for interventional studies

Cholecalciferol

Calcifediol

Active form of vitamin D3, 1, 25-dihydroxyvitamin D3 (1,25D3), calcitriol, is
pluripotent hormone and important modulator of both innate and adaptive immunityShow More

Comorbid diseases

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